Are Thyroid Biopsies Accurate?

Can FNA results be wrong?

The false-negative rates of FNA for thyroid nodules reported by most studies are less than 5% [11,12,13,14,15,16].

However, higher rates (varying from 7.5 to 21%) have also been published in other study series [17,18,19,20,21,22]..

What is Stage 1 thyroid cancer?

Stage I papillary and follicular thyroid cancer in patients younger than 55 years. The tumor is any size and cancer may have spread to nearby tissues and lymph nodes. Cancer has not spread to other parts of the body. Stage II papillary and follicular thyroid cancer in patients younger than 55 years.

At what size should a thyroid nodule be biopsied?

According to the Society of Radiologists in Ultrasound, biopsy should be performed on a nodule 1 cm in diameter or larger with microcalcifications, 1.5 cm in diameter or larger that is solid or has coarse calcifications, and 2 cm in diameter or larger that has mixed solid and cystic components, and a nodule that has …

What does moderately suspicious mean?

“Moderately suspicious” or TR4 nodules are 4 to 6 points, and TR5 nodules or “highly suspicious” have sums of 7 points or more. For TR4 nodules, the guidelines recommend fine-needle aspiration if the nodule is 1.5cm or larger, and follow-ups if larger than 1cm.

What percent of thyroid biopsies are cancerous?

While most thyroid nodules are non-cancerous (Benign), ~5% are cancerous.

Can a negative biopsy be wrong?

One study looking at nearly 1,000 core needle biopsies found a false negative result rate of 2.2%. That’s just over 2 out of 100 biopsies. Sensitivity and specificity are two terms you may hear when talking about testing accuracy, including screening tests.

How often are thyroid biopsies wrong?

This and other studies show that FNAB is currently the best means of identifying thyroid cancer. In this study, 1.9% of the biopsies initially read as benign were eventually found to contain a cancer (false negative). In other studies, the false negative rate has ranged from 1 to 11%.

What does a suspicious thyroid biopsy mean?

“Suspicious” thyroid biopsy: this happens usually when the diagnosis is a follicular or hurtle cell caused lesion. Follicular and hurtle cells are normal cells found in the thyroid. Current analysis of thyroid biopsy results cannot differentiate between follicular or hurtle cell cancer from noncancerous adenomas.

What size thyroid nodule is worrisome?

If the TSH is normal or high, then most individuals with a thyroid nodule larger than 1.0 to 1.5 cm (1/2 inch) in diameter as well as those with a suspicious goiter need to have a fine needle aspiration biopsy to obtain thyroid cells for cytologic evaluation by an expert pathologist.

How accurate are fine needle biopsy?

Fine-needle aspiration biopsy (FNAB) is an efficient and reliable means for the evaluation of thyroid nodules, and it has been shown to have a diagnostic sensitivity of 89% to 98% and a specificity of 92%.

Why do I need a second biopsy?

Sometimes a biopsy sample might not be big enough to evaluate. Other times, the pathologist can see that the sample was not taken from the correct area. In these cases, the pathologist will ask your doctor to repeat the biopsy, so the pathologist can make a conclusive and accurate diagnosis.

What makes a thyroid nodule suspicious?

Most thyroid nodules are asymptomatic, non-palpable and only detected on ultrasound or other anatomic imaging studies. The following characteristics increase the suspicion of cancer: Swelling in the neck. A rapidly growing nodule.

Why do biopsies take so long?

After the first sections of tissue are seen under the microscope, the pathologist might want to look at more sections for an accurate diagnosis. In these cases, extra pieces of tissue might need processing. Or the lab may need to make more slices of the tissue that has already been embedded in wax blocks.

What are early warning signs of thyroid cancer?

Signs and Symptoms of Thyroid CancerA lump in the neck, sometimes growing quickly.Swelling in the neck.Pain in the front of the neck, sometimes going up to the ears.Hoarseness or other voice changes that do not go away.Trouble swallowing.Trouble breathing.A constant cough that is not due to a cold.

How painful is a thyroid biopsy?

A needle biopsy is less invasive than open and closed surgical biopsies, both of which involve a larger incision in the skin and local or general anesthesia. Generally, the procedure is not painful and the results are as accurate as when a tissue sample is removed surgically.